Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetNitric oxide scavenging action

General description

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.Hogg, N., et al. 1995. Free Radical Res.22, 47.Az-ma, T., et al. 1994. Life Sci.54, 185.Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.Akaike, T., et al. 1993. Biochemistry32, 827.Yoshida, K., et al. 1993. Infect. Immun.61, 3552.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.

Warning

Toxicity: Standard Handling (A)